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An acid-loading chloride transport pathway in the intraerythrocytic malaria parasite, Plasmodium falciparum

Henry, Roselani; Cobbold, Simon; Allen, Richard; Khan, Asif; Hayward, Rhys; Lehane, Adele; Bray, Patrick; Howitt, Susan; Biagini, Giancarlo A; Saliba, Kevin; Kirk, Kiaran


The intraerythrocytic malaria parasite exerts tight control over its ionic composition. In this study, a combination of fluorescent ion indicators and36Cl- flux measurements was used to investigate the transport of Cl- and the Cl--dependent transport of "H+-equivalents" in mature (trophozoite stage) parasites, isolated from their host erythrocytes. Removal of extracellular Cl-, resulting in an outward [Cl-] gradient, gave rise to a cytosolic alkalinization (i.e. a net efflux of H+-equivalents)....[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M110.120980


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