An acid-loading chloride transport pathway in the intraerythrocytic malaria parasite, Plasmodium falciparum
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Henry, Roselani; Cobbold, Simon; Allen, Richard; Khan, Asif; Hayward, Rhys; Lehane, Adele; Bray, Patrick; Howitt, Susan; Biagini, Giancarlo A; Saliba, Kevin; Kirk, Kiaran
Description
The intraerythrocytic malaria parasite exerts tight control over its ionic composition. In this study, a combination of fluorescent ion indicators and36Cl- flux measurements was used to investigate the transport of Cl- and the Cl--dependent transport of "H+-equivalents" in mature (trophozoite stage) parasites, isolated from their host erythrocytes. Removal of extracellular Cl-, resulting in an outward [Cl-] gradient, gave rise to a cytosolic alkalinization (i.e. a net efflux of H+-equivalents)....[Show more]
Collections | ANU Research Publications |
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Date published: | 2010 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/34753 |
Source: | Journal of Biological Chemistry |
DOI: | 10.1074/jbc.M110.120980 |
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01_Henry_An_acid-loading_chloride_2010.pdf | 2.67 MB | Adobe PDF | Request a copy |
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