IL-12p40 and IL-18 Play Pivotal Roles in Orchestrating the Cell-Mediated Immune Response to a Poxvirus Infection
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Wang, Yang; Chaudhri, Geeta; Jackson, Ronald; Karupiah, Gunasegaran
Description
A strong cell-mediated immune response is critical for controlling viral infections and is regulated by a number of cytokines, including IL-12 and IL-18. Indeed, some viruses have evolved to specifically target these pathways to counter the host immune response. Orthopoxviruses, including ectromelia virus, encode immune evasion molecules that specifically target IL-18 and IFN-γ. We hypothesized that IL-12 and IL-18 are pivotal for induction of IFN-γ production and subsequent generation of an...[Show more]
Collections | ANU Research Publications |
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Date published: | 2009 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/34748 |
Source: | Journal of Immunology |
DOI: | 10.4049/jimmunol.0803985 |
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01_Wang_IL-12p40_and_IL-18_Play_2009.pdf | 1.88 MB | Adobe PDF | Request a copy |
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