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IL-12p40 and IL-18 Play Pivotal Roles in Orchestrating the Cell-Mediated Immune Response to a Poxvirus Infection

Wang, Yang; Chaudhri, Geeta; Jackson, Ronald; Karupiah, Gunasegaran


A strong cell-mediated immune response is critical for controlling viral infections and is regulated by a number of cytokines, including IL-12 and IL-18. Indeed, some viruses have evolved to specifically target these pathways to counter the host immune response. Orthopoxviruses, including ectromelia virus, encode immune evasion molecules that specifically target IL-18 and IFN-γ. We hypothesized that IL-12 and IL-18 are pivotal for induction of IFN-γ production and subsequent generation of an...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Journal of Immunology
DOI: 10.4049/jimmunol.0803985


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