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Glutathione Transferase P1: An Endogenous Inhibitor of Allergic Responses in a Mouse Model of Asthma

Zhou, Jiansheng; Wolf, C Roland; Henderson, Colin J; Cai, Yeping; Board, Philip; Foster, Paul S; Webb, Dianne

Description

Rationale: Although epidemiological studies have linked asthma susceptibility and severity to polymorphisms in human glutathione transferase Pi (GSTP) 1, there is no direct evidence for a functional involvement of GSTP1 in processes that are pathognomic of asthma. Objectives: To examine the role of GSTP1 in modulating the development of allergic airways disease. Methods: Allergic airways disease was induced in wild-type (WT) and Gstp-null mice employing both acute and chronic models....[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
URI: http://hdl.handle.net/1885/34700
Source: American Journal of Respiratory and Critical Care Medicine
DOI: 10.1164/rccm.200801-178OC

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