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Indian hedgehog supports definitive erythropoiesis

Cridland, Simon O; Keys, Janelle R.; Papathanasiou, Panagiotis; Perkins, Andrew C.

Description

Indian hedgehog (Ihh) has been reported to stimulate haematopoiesis ex vivo. In this study we studied the consequences of loss of function of Ihh for murine haematopoietic development. Ihh has no essential role in primitive erythropoiesis, but it is required in a non cell autonomous fashion for definitive erythropoieisis. Many components of the hedgehog signaling pathway are present in the fetal liver, with Ihh and Gli1 being most highly expressed in the stroma and Ptc1 being most highly...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
URI: http://hdl.handle.net/1885/34658
Source: Blood cells, Molecules and Diseases
DOI: 10.1016/j.bcmd.2009.04.004

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