Indian hedgehog supports definitive erythropoiesis
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Cridland, Simon O; Keys, Janelle R.; Papathanasiou, Panagiotis; Perkins, Andrew C.
Description
Indian hedgehog (Ihh) has been reported to stimulate haematopoiesis ex vivo. In this study we studied the consequences of loss of function of Ihh for murine haematopoietic development. Ihh has no essential role in primitive erythropoiesis, but it is required in a non cell autonomous fashion for definitive erythropoieisis. Many components of the hedgehog signaling pathway are present in the fetal liver, with Ihh and Gli1 being most highly expressed in the stroma and Ptc1 being most highly...[Show more]
Collections | ANU Research Publications |
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Date published: | 2009 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/34658 |
Source: | Blood cells, Molecules and Diseases |
DOI: | 10.1016/j.bcmd.2009.04.004 |
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