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Investigation of causes of oseltamivir chemoprophylaxis failures during influenza A (H1N1-2009) outbreaks

Lee, Vernon; Yap, Jonathan; Maurer-Stroh, Sebastian; Lee, Raphael T.C.; Eisenhaber, Frank; Tay, Joshua K; Ting, Pei Jun; Loh, Jin Phang; Wong, Christopher W.; Tan, Boon Huan; Koay, Evelyn S.C.; Kelly, Paul; Hibberd, Martin L.

Description

Background: Antiviral post-exposure prophylaxis with oseltamivir has been used as a strategy in mitigating the Influenza A (H1N1-2009) pandemic. There have been few reports of well-documented prophylaxis failures and the reasons for failure. Objectives: We report herein a series of 10 cases of prophylaxis failures and explore the reasons behind their prophylaxis failure. Study design: In the early pandemic phase, the military employed oseltamivir post-exposure ring-prophylaxis of affected...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
URI: http://hdl.handle.net/1885/34635
Source: Journal of Clinical Virology
DOI: 10.1016/j.jcv.2010.10.004

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