Investigation of causes of oseltamivir chemoprophylaxis failures during influenza A (H1N1-2009) outbreaks
Lee, Vernon; Yap, Jonathan; Maurer-Stroh, Sebastian; Lee, Raphael T.C.; Eisenhaber, Frank; Tay, Joshua K; Ting, Pei Jun; Loh, Jin Phang; Wong, Christopher W.; Tan, Boon Huan; Koay, Evelyn S.C.; Kelly, Paul; Hibberd, Martin L.
Background: Antiviral post-exposure prophylaxis with oseltamivir has been used as a strategy in mitigating the Influenza A (H1N1-2009) pandemic. There have been few reports of well-documented prophylaxis failures and the reasons for failure. Objectives: We report herein a series of 10 cases of prophylaxis failures and explore the reasons behind their prophylaxis failure. Study design: In the early pandemic phase, the military employed oseltamivir post-exposure ring-prophylaxis of affected...[Show more]
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|Source:||Journal of Clinical Virology|
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