Understanding the role of inflammatory cytokines in malaria and related diseases
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Clark, Ian A; Alleva, Lisa; Budd, Alison; Cowden, William
Description
It is now broadly accepted for infectious disease in general that it is not the invading organism, but the body's unbridled response to it-the "cytokine storm"-that causes illness and pathology. Nevertheless, many researchers still regard the harmful effects of falciparum malaria as being governed by oligaemic hypoxia arising from parasitised erythrocytes obstructing blood flow through vulnerable organs, particularly the brain, and we summarise why these notions are no longer tenable. In our...[Show more]
dc.contributor.author | Clark, Ian A | |
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dc.contributor.author | Alleva, Lisa | |
dc.contributor.author | Budd, Alison | |
dc.contributor.author | Cowden, William | |
dc.date.accessioned | 2015-12-08T22:33:19Z | |
dc.identifier.issn | 1477-8939 | |
dc.identifier.uri | http://hdl.handle.net/1885/34625 | |
dc.description.abstract | It is now broadly accepted for infectious disease in general that it is not the invading organism, but the body's unbridled response to it-the "cytokine storm"-that causes illness and pathology. Nevertheless, many researchers still regard the harmful effects of falciparum malaria as being governed by oligaemic hypoxia arising from parasitised erythrocytes obstructing blood flow through vulnerable organs, particularly the brain, and we summarise why these notions are no longer tenable. In our view, this harmful sequestration is readily accommodated within the cytokine storm perspective as one of its secondary effects. We approach these issues by examining aspects of malaria, sepsis and influenza in parallel, and discuss the insights that comparisons of the literature can provide on the validity of possible anti-disease therapies. | |
dc.publisher | Elsevier | |
dc.source | Travel Medicine and Infectious Disease | |
dc.subject | Keywords: arginine; BCG vaccine; carbon monoxide; cytokine; dichloroacetic acid; Fas ligand; gemfibrozil; hemin; interleukin 1; interleukin 10; interleukin 4; interleukin 6; lymphotoxin; nitric oxide; OKT 3; recombinant tumor necrosis factor; transforming growth fa Cytokine storm; Influenza; Malaria; Sepsis; TNF | |
dc.title | Understanding the role of inflammatory cytokines in malaria and related diseases | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 6 | |
dc.date.issued | 2008 | |
local.identifier.absfor | 110802 - Medical Infection Agents (incl. Prions) | |
local.identifier.absfor | 110799 - Immunology not elsewhere classified | |
local.identifier.absfor | 110803 - Medical Parasitology | |
local.identifier.ariespublication | u4325460xPUB115 | |
local.type.status | Published Version | |
local.contributor.affiliation | Clark, Ian A, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Alleva, Lisa, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Budd, Alison, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Cowden, William, College of Medicine, Biology and Environment, ANU | |
local.description.embargo | 2037-12-31 | |
local.bibliographicCitation.startpage | 67 | |
local.bibliographicCitation.lastpage | 81 | |
local.identifier.doi | 10.1016/j.tmaid.2007.07.002 | |
dc.date.updated | 2015-12-08T09:34:37Z | |
local.identifier.scopusID | 2-s2.0-40649097787 | |
Collections | ANU Research Publications |
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