Clark, Ian A; Alleva, Lisa; Budd, Alison; Cowden, William
It is now broadly accepted for infectious disease in general that it is not the invading organism, but the body's unbridled response to it-the "cytokine storm"-that causes illness and pathology. Nevertheless, many researchers still regard the harmful effects of falciparum malaria as being governed by oligaemic hypoxia arising from parasitised erythrocytes obstructing blood flow through vulnerable organs, particularly the brain, and we summarise why these notions are no longer tenable. In our...[Show more]
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