Self-Renewal of the Long-Term Reconstituting Subset of Hematopoietic Stem Cells is Regulated by Ikaros
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Papathanasiou, Peter; Attema, Joanne L.; Karsunky, Holger; Hosen, Naoki; Sontani, Yovina; Hoyne, Gerard; Tunningley, Robert; Smale, Stephen T; Weissman, Irving L.
Description
Hematopoietic stem cells (HSCs) are rare, ancestral cells that underlie the development, homeostasis, aging, and regeneration of the blood. Here we show that the chromatin-associated protein Ikaros is a crucial self-renewal regulator of the long-term (LT) reconstituting subset of HSCs. Ikaros, and associated family member proteins, are highly expressed in self-renewing populations of stem cells. Ikaros point mutant mice initially develop LT-HSCs with the surface phenotype...[Show more]
Collections | ANU Research Publications |
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Date published: | 2009 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/34568 |
Source: | Stem Cells |
DOI: | 10.1002/stem.232 |
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01_Papathanasiou_Self-Renewal_of_the_Long-Term_2009.pdf | 944.98 kB | Adobe PDF | Request a copy |
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