Skip navigation
Skip navigation

Self-Renewal of the Long-Term Reconstituting Subset of Hematopoietic Stem Cells is Regulated by Ikaros

Papathanasiou, Peter; Attema, Joanne L.; Karsunky, Holger; Hosen, Naoki; Sontani, Yovina; Hoyne, Gerard; Tunningley, Robert; Smale, Stephen T; Weissman, Irving L.

Description

Hematopoietic stem cells (HSCs) are rare, ancestral cells that underlie the development, homeostasis, aging, and regeneration of the blood. Here we show that the chromatin-associated protein Ikaros is a crucial self-renewal regulator of the long-term (LT) reconstituting subset of HSCs. Ikaros, and associated family member proteins, are highly expressed in self-renewing populations of stem cells. Ikaros point mutant mice initially develop LT-HSCs with the surface phenotype...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
URI: http://hdl.handle.net/1885/34568
Source: Stem Cells
DOI: 10.1002/stem.232

Download

File Description SizeFormat Image
01_Papathanasiou_Self-Renewal_of_the_Long-Term_2009.pdf944.98 kBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  20 July 2017/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator