Papathanasiou, Peter; Attema, Joanne L.; Karsunky, Holger; Hosen, Naoki; Sontani, Yovina; Hoyne, Gerard; Tunningley, Robert; Smale, Stephen T; Weissman, Irving L.
Hematopoietic stem cells (HSCs) are rare, ancestral cells that underlie the development, homeostasis, aging, and regeneration of the blood. Here we show that the chromatin-associated protein Ikaros is a crucial self-renewal regulator of the long-term (LT) reconstituting subset of HSCs. Ikaros, and associated family member proteins, are highly expressed in self-renewing populations of stem cells. Ikaros point mutant mice initially develop LT-HSCs with the surface phenotype...[Show more]
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.