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Activation of cathepsin D by glycosaminoglycans

Beckman, Marie; Freeman, Craig; Small, David H; Parish, Christopher

Description

We have previously shown that heparin can increase the activity of the proenzyme form of Alzheimer's β-site amyloid precursor protein cleaving enzyme 1 (BACE1). Cathepsin D (CD) is a member of the aspartic protease family and has sequence similarity to B

dc.contributor.authorBeckman, Marie
dc.contributor.authorFreeman, Craig
dc.contributor.authorSmall, David H
dc.contributor.authorParish, Christopher
dc.date.accessioned2015-12-08T22:30:30Z
dc.identifier.issn1742-464X
dc.identifier.urihttp://hdl.handle.net/1885/34484
dc.description.abstractWe have previously shown that heparin can increase the activity of the proenzyme form of Alzheimer's β-site amyloid precursor protein cleaving enzyme 1 (BACE1). Cathepsin D (CD) is a member of the aspartic protease family and has sequence similarity to B
dc.publisherBlackwell Publishing Ltd
dc.sourceThe FEBS Journal
dc.subjectKeywords: amino acid; cathepsin D; enzyme precursor; glycosaminoglycan; heparin; procathepsin d; sulfate; unclassified drug; amino acid sequence; article; catalysis; controlled study; drug potency; enzyme activation; enzyme active site; enzyme activity; enzyme regu Aspartic protease; Cathepsin D; Glycosaminoglycan; Heparin; Proteolytic activity
dc.titleActivation of cathepsin D by glycosaminoglycans
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume276
dc.date.issued2009
local.identifier.absfor110102 - Medical Biochemistry: Carbohydrates
local.identifier.ariespublicationu6800332xPUB113
local.type.statusPublished Version
local.contributor.affiliationBeckman, Marie, Monash University
local.contributor.affiliationFreeman, Craig, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationParish, Christopher, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationSmall, David H, University of Tasmania
local.description.embargo2037-12-31
local.bibliographicCitation.startpage7343
local.bibliographicCitation.lastpage7352
local.identifier.doi10.1111/j.1742-4658.2009.07444.x
dc.date.updated2016-02-24T11:37:38Z
local.identifier.scopusID2-s2.0-71949093178
local.identifier.thomsonID000272172600013
CollectionsANU Research Publications

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