Skip navigation
Skip navigation

T cell receptor sharing by cytotoxic T lymphocytes facilitates efficient virus control

Chaudhri, Geeta; Quah, Ben; Wang, Yang; Tan, Abel; Zhou, Jie; Karupiah, Gunasegaran; Parish, Christopher

Description

A remarkable feature of the adaptive immune system is the speed at which small numbers of antigen-specific lymphocytes can mediate a successful immune response. Rapid expansion of T and B lymphocyte clones that have receptors specific for a particular antigen is one of the primary means by which a swift response is generated. Although much of this clonal expansion is caused by the division of antigen-specific cells, herewedemonstrate an additional mechanism by which the pool of effector T cells...[Show more]

dc.contributor.authorChaudhri, Geeta
dc.contributor.authorQuah, Ben
dc.contributor.authorWang, Yang
dc.contributor.authorTan, Abel
dc.contributor.authorZhou, Jie
dc.contributor.authorKarupiah, Gunasegaran
dc.contributor.authorParish, Christopher
dc.date.accessioned2015-12-08T22:30:20Z
dc.identifier.issn0027-8424
dc.identifier.urihttp://hdl.handle.net/1885/34390
dc.description.abstractA remarkable feature of the adaptive immune system is the speed at which small numbers of antigen-specific lymphocytes can mediate a successful immune response. Rapid expansion of T and B lymphocyte clones that have receptors specific for a particular antigen is one of the primary means by which a swift response is generated. Although much of this clonal expansion is caused by the division of antigen-specific cells, herewedemonstrate an additional mechanism by which the pool of effector T cells against a viral infection can quickly enlarge. Our data show that virus-specific CD8+ cytotoxic T lymphocytes (CTL) can transfer their T cell receptors (TCR) to recipient CTL of an unrelated specificity that, as a consequence, gain the antigen specificity of the donor T cell. This process occurs within minutes via membrane exchange and results in the recipient CTL acquiring the ability to recognize and eliminate cells targeted by the donor TCR, while still retaining the antigen specificity of its own TCR. Such receptor sharing allows rapid, proliferation-independent expansion of virus-specific T cell clones of low frequency and plays a highly significant antiviral role that can protect the host from an otherwise lethal infection.
dc.publisherNational Academy of Sciences (USA)
dc.sourcePNAS - Proceedings of the National Academy of Sciences of the United States of America
dc.subjectKeywords: T lymphocyte receptor; animal experiment; animal model; antigen specificity; article; CD8+ T lymphocyte; cytotoxic T lymphocyte; Ectromelia virus; female; immune response; mouse; nonhuman; priority journal; virus immunity; virus infection; Animals; Cell M Antigen receptor transfer; Clonal expansion; Clonal selection theory; Poxvirus; Trogocytosis
dc.titleT cell receptor sharing by cytotoxic T lymphocytes facilitates efficient virus control
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume106
dc.date.issued2009
local.identifier.absfor110704 - Cellular Immunology
local.identifier.ariespublicationu6800332xPUB112
local.type.statusPublished Version
local.contributor.affiliationChaudhri, Geeta, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationQuah, Ben, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationWang, Yang, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationTan, Abel, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationZhou, Jie, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationKarupiah, Gunasegaran, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationParish, Christopher, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.issue35
local.bibliographicCitation.startpage14984
local.bibliographicCitation.lastpage14989
local.identifier.doi10.1073/pnas.0906554106
dc.date.updated2016-02-24T11:37:37Z
local.identifier.scopusID2-s2.0-70349299914
local.identifier.thomsonID000269481000046
CollectionsANU Research Publications

Download

File Description SizeFormat Image
01_Chaudhri_T_cell_receptor_sharing_by_2009.pdf1.9 MBAdobe PDFThumbnail
    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator