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T cell receptor sharing by cytotoxic T lymphocytes facilitates efficient virus control

Chaudhri, Geeta; Quah, Ben; Wang, Yang; Tan, Abel; Zhou, Jie; Karupiah, Gunasegaran; Parish, Christopher

Description

A remarkable feature of the adaptive immune system is the speed at which small numbers of antigen-specific lymphocytes can mediate a successful immune response. Rapid expansion of T and B lymphocyte clones that have receptors specific for a particular antigen is one of the primary means by which a swift response is generated. Although much of this clonal expansion is caused by the division of antigen-specific cells, herewedemonstrate an additional mechanism by which the pool of effector T cells...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
URI: http://hdl.handle.net/1885/34390
Source: PNAS - Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.0906554106

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