Relationship between C-reactive protein concentration and cytokine responses to exercise in healthy and illness-prone runners
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Cox, Amanda J; Pyne, David; Gleeson, Maree; Callister, R.J.
Description
Differences in the immune and inflammatory response to exercise between healthy and illness-prone athletes may be one explanation why some athletes experience a greater incidence of upper respiratory symptoms than others. The aim of this study was to compare the C-reactive protein (CRP) response to acute exercise between healthy and illness-prone trained distance runners. Runners were classified as healthy (≤2 episodes of upper respiratory symptoms per year; n = 10) or illness-prone (≥4...[Show more]
dc.contributor.author | Cox, Amanda J | |
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dc.contributor.author | Pyne, David | |
dc.contributor.author | Gleeson, Maree | |
dc.contributor.author | Callister, R.J. | |
dc.date.accessioned | 2015-12-08T22:30:04Z | |
dc.identifier.issn | 1439-6319 | |
dc.identifier.uri | http://hdl.handle.net/1885/34349 | |
dc.description.abstract | Differences in the immune and inflammatory response to exercise between healthy and illness-prone athletes may be one explanation why some athletes experience a greater incidence of upper respiratory symptoms than others. The aim of this study was to compare the C-reactive protein (CRP) response to acute exercise between healthy and illness-prone trained distance runners. Runners were classified as healthy (≤2 episodes of upper respiratory symptoms per year; n = 10) or illness-prone (≥4 episodes per year; n = 8) and completed three treadmill running protocols. CRP concentrations were determined prior to and 24 h following each exercise protocol and responses compared between the two groups. Plasma concentrations of Interleukin (IL)-6, IL-8, IL-10 and the IL-1 receptor antagonist (IL-1ra) were also determined immediately, 1 h, 10 h and 24 h post-exercise. The CRP response at 24 h post-exercise was not substantially different between healthy and illness-prone athletes (∼2-10%). There were small to moderate correlations between resting CRP concentrations and the peak IL-6 (r = 0.28, P = 0.04), IL-8 (r = 0.31, P = 0.03), IL-10 (r = 0.28, P = 0.05) and IL-1ra (r = 0.30, P = 0.03) concentrations post-exercise. The CRP response to exercise was not useful in distinguishing between healthy and illness-prone athletes. The relationship between resting CRP concentrations and the peak pro- and anti-inflammatory responses to exercise supports the likely involvement of CRP in the complex network regulating exercise-induced inflammatory disturbance. | |
dc.publisher | Springer | |
dc.source | European Journal of Applied Physiology | |
dc.subject | Keywords: C reactive protein; cytokine; interleukin 1 receptor blocking agent; interleukin 10; interleukin 11; interleukin 6; interleukin 8; article; athlete; concentration (parameters); exercise; exercise test; human; human experiment; male; normal human; priority Athletes; Cytokines; Exercise; Inflammation | |
dc.title | Relationship between C-reactive protein concentration and cytokine responses to exercise in healthy and illness-prone runners | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 107 | |
dc.date.issued | 2009 | |
local.identifier.absfor | 110604 - Sports Medicine | |
local.identifier.ariespublication | u4201517xPUB112 | |
local.type.status | Published Version | |
local.contributor.affiliation | Cox, Amanda J, University of Newcastle | |
local.contributor.affiliation | Pyne, David, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Gleeson, Maree, University of Newcastle | |
local.contributor.affiliation | Callister, R.J., University of Newcastle | |
local.description.embargo | 2037-12-31 | |
local.bibliographicCitation.startpage | 611 | |
local.bibliographicCitation.lastpage | 614 | |
local.identifier.doi | 10.1007/s00421-009-1160-0 | |
dc.date.updated | 2016-02-24T10:40:28Z | |
local.identifier.scopusID | 2-s2.0-70350669535 | |
Collections | ANU Research Publications |
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