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Relationship between C-reactive protein concentration and cytokine responses to exercise in healthy and illness-prone runners

Cox, Amanda J; Pyne, David; Gleeson, Maree; Callister, R.J.

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Differences in the immune and inflammatory response to exercise between healthy and illness-prone athletes may be one explanation why some athletes experience a greater incidence of upper respiratory symptoms than others. The aim of this study was to compare the C-reactive protein (CRP) response to acute exercise between healthy and illness-prone trained distance runners. Runners were classified as healthy (≤2 episodes of upper respiratory symptoms per year; n = 10) or illness-prone (≥4...[Show more]

dc.contributor.authorCox, Amanda J
dc.contributor.authorPyne, David
dc.contributor.authorGleeson, Maree
dc.contributor.authorCallister, R.J.
dc.date.accessioned2015-12-08T22:30:04Z
dc.identifier.issn1439-6319
dc.identifier.urihttp://hdl.handle.net/1885/34349
dc.description.abstractDifferences in the immune and inflammatory response to exercise between healthy and illness-prone athletes may be one explanation why some athletes experience a greater incidence of upper respiratory symptoms than others. The aim of this study was to compare the C-reactive protein (CRP) response to acute exercise between healthy and illness-prone trained distance runners. Runners were classified as healthy (≤2 episodes of upper respiratory symptoms per year; n = 10) or illness-prone (≥4 episodes per year; n = 8) and completed three treadmill running protocols. CRP concentrations were determined prior to and 24 h following each exercise protocol and responses compared between the two groups. Plasma concentrations of Interleukin (IL)-6, IL-8, IL-10 and the IL-1 receptor antagonist (IL-1ra) were also determined immediately, 1 h, 10 h and 24 h post-exercise. The CRP response at 24 h post-exercise was not substantially different between healthy and illness-prone athletes (∼2-10%). There were small to moderate correlations between resting CRP concentrations and the peak IL-6 (r = 0.28, P = 0.04), IL-8 (r = 0.31, P = 0.03), IL-10 (r = 0.28, P = 0.05) and IL-1ra (r = 0.30, P = 0.03) concentrations post-exercise. The CRP response to exercise was not useful in distinguishing between healthy and illness-prone athletes. The relationship between resting CRP concentrations and the peak pro- and anti-inflammatory responses to exercise supports the likely involvement of CRP in the complex network regulating exercise-induced inflammatory disturbance.
dc.publisherSpringer
dc.sourceEuropean Journal of Applied Physiology
dc.subjectKeywords: C reactive protein; cytokine; interleukin 1 receptor blocking agent; interleukin 10; interleukin 11; interleukin 6; interleukin 8; article; athlete; concentration (parameters); exercise; exercise test; human; human experiment; male; normal human; priority Athletes; Cytokines; Exercise; Inflammation
dc.titleRelationship between C-reactive protein concentration and cytokine responses to exercise in healthy and illness-prone runners
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume107
dc.date.issued2009
local.identifier.absfor110604 - Sports Medicine
local.identifier.ariespublicationu4201517xPUB112
local.type.statusPublished Version
local.contributor.affiliationCox, Amanda J, University of Newcastle
local.contributor.affiliationPyne, David, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationGleeson, Maree, University of Newcastle
local.contributor.affiliationCallister, R.J., University of Newcastle
local.description.embargo2037-12-31
local.bibliographicCitation.startpage611
local.bibliographicCitation.lastpage614
local.identifier.doi10.1007/s00421-009-1160-0
dc.date.updated2016-02-24T10:40:28Z
local.identifier.scopusID2-s2.0-70350669535
CollectionsANU Research Publications

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