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Characterization of Colonic and Mesenteric Lymph Node Dendritic Cell Subpopulations in a Murine Adoptive Transfer Model of Inflammatory Bowel Disease

Karlis, John; Penttila, Irmeli; Tran , Tuyet B; Jones, Ben; Nobbs, Sylvia; Zola, Heddy; Flesch, Inge


Ulcerative colitis and Crohn's disease, collectively termed inflammatory bowel diseases (IBD), are chronic inflammatory diseases of the intestine that afflict more than 4 million people worldwide. Intestinal inflammation is characterized by an abnormal mucosal immune response to normally harmless antigens in the gut flora. In Crohn's disease, the pathogenic mucosal immune response is a typical T helper (TH1) type cell response, whereas ulcerative colitis is predominantly associated with a TH2...[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
Source: Inflammatory Bowel Diseases
DOI: 10.1097/00054725-200411000-00018


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