Characterization of Colonic and Mesenteric Lymph Node Dendritic Cell Subpopulations in a Murine Adoptive Transfer Model of Inflammatory Bowel Disease
Ulcerative colitis and Crohn's disease, collectively termed inflammatory bowel diseases (IBD), are chronic inflammatory diseases of the intestine that afflict more than 4 million people worldwide. Intestinal inflammation is characterized by an abnormal mucosal immune response to normally harmless antigens in the gut flora. In Crohn's disease, the pathogenic mucosal immune response is a typical T helper (TH1) type cell response, whereas ulcerative colitis is predominantly associated with a TH2...[Show more]
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|Source:||Inflammatory Bowel Diseases|
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