T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow
Jenne, Craig N; Enders, Anselm; Rivera, Richard; Watson, Susan R; Bankovich, Alexander J.; Pereira, Joao P.; Xu, Ying; Roots, Carla; Beilke, Joshua N.; Banerjee, Arnob; Reiner, Steven L.; Miller, Sara A.; Weinmann, Amy S.; Goodnow, Christopher; Lanier, Lewis L; Cyster, Jason G; Chun, Jerold
During a screen for ethylnitrosourea-induced mutations in mice affecting blood natural killer (NK) cells, we identified a strain, designated Duane, in which NK cells were reduced in blood and spleen but increased in lymph nodes (LNs) and bone marrow (BM). The accumulation of NK cells in LNs reflected a decreased ability to exit into lymph. This strain carries a point mutation within Tbx21 (T-bet), which generates a defective protein. Duane NK cells have a 30-fold deficiency in...[Show more]
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