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A novel selenium-containing glutathione transferase zeta1-1, the activity of which surpasses the level of some native glutathione peroxidases

Zheng, Keyan; Board, Philip; Fei, Xiaofang; Sun, Ye; Lv, Shaowu; Yan, Ganglin; Liu, Junqiu; Shen, Jiacong; Luo, Guimin


Glutathione peroxidase (GPX) is a critical antioxidant selenoenzyme in organisms that protects cells against oxidative damage by catalyzing the reduction of hydroperoxides by glutathione (GSH). Thus, some GPX mimics have been generated because of their potential therapeutic value. The generation of a semisynthetic selenoenzyme with peroxidase activity, which matches the catalytic efficiencies of naturally evolved GPX, has been a great challenge. Previously, we semisynthesized a GPX mimetic with...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: The International Journal of Biochemistry and Cell Biology
DOI: 10.1016/j.biocel.2008.02.006


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