Mental health literacy, folic acid and vitamin B 12 , and physical activity for the prevention of depression in older adults: Randomised controlled trial
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Walker, Janine; Mackinnon, Andrew; Batterham, Philip; Jorm, Anthony F; Hickie, Ian B; Jenkins (previously McCarthy), Affrica; Fenech, Michael; Christensen, Helen
Description
Background: Few randomised controlled trials (RCTs) have examined potential preventive agents in high-risk community populations. Aims: To determine whether a mental health literacy intervention, the promotion of physical activity, or folic acid plus vitamin B12 reduce depression symptoms in community-dwelling older adults with elevated psychological distress. Method: An RCT with a completely crossed 2x2x2 factorial design: (400 mcg/d folic acid + 100 mcg/d vitamin B12 v. placebo)x(physical...[Show more]
dc.contributor.author | Walker, Janine | |
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dc.contributor.author | Mackinnon, Andrew | |
dc.contributor.author | Batterham, Philip | |
dc.contributor.author | Jorm, Anthony F | |
dc.contributor.author | Hickie, Ian B | |
dc.contributor.author | Jenkins (previously McCarthy), Affrica | |
dc.contributor.author | Fenech, Michael | |
dc.contributor.author | Christensen, Helen | |
dc.date.accessioned | 2015-12-08T22:29:35Z | |
dc.date.available | 2015-12-08T22:29:35Z | |
dc.identifier.issn | 0007-1250 | |
dc.identifier.uri | http://hdl.handle.net/1885/34149 | |
dc.description.abstract | Background: Few randomised controlled trials (RCTs) have examined potential preventive agents in high-risk community populations. Aims: To determine whether a mental health literacy intervention, the promotion of physical activity, or folic acid plus vitamin B12 reduce depression symptoms in community-dwelling older adults with elevated psychological distress. Method: An RCT with a completely crossed 2x2x2 factorial design: (400 mcg/d folic acid + 100 mcg/d vitamin B12 v. placebo)x(physical activity v. nutrition promotion control)x(mental health literacy v. pain information control). The initial target sample size was 2000; however, only 909 adults (60-74 years) met the study criteria. Interventions were delivered by mail with telephone calls. The main outcome was depressive symptoms on the Patient Health Questionnaire (PHQ-9) at 6 weeks, 6, 12 and 24 months. The Clinicaltrials.gov registration number is NCT00214682. Results: The drop-out rate was low (13.5%) from randomisation to 24-month assessment. Neither folic acid + B12 (F(3,856) = 0.83, P = 0.476) nor physical activity (F(3,856) = 1.65, P = 0.177) reduced depressive symptoms at any time point. At 6 weeks, depressive symptoms were lower for the mental health literacy intervention compared with its control condition (t(895) = 2.04, P = 0.042). Conclusions: Mental health literacy had a transient effect on depressive symptoms. Other than this, none of the interventions significantly reduced symptoms relative to their comparator at 6 weeks or subsequently. Neither folic acid plus B12 nor physical activity were effective in reducing depressive symptoms. | |
dc.publisher | Royal College of Psychiatrists | |
dc.source | British Journal of Psychiatry | |
dc.subject | Keywords: cyanocobalamin; folic acid; placebo; absence of side effects; adult; aged; article; clinical trial; controlled clinical trial; controlled study; depression; distress syndrome; drug safety; female; health survey; human; male; medical information; mental he | |
dc.title | Mental health literacy, folic acid and vitamin B 12 , and physical activity for the prevention of depression in older adults: Randomised controlled trial | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 197 | |
dc.date.issued | 2010 | |
local.identifier.absfor | 111714 - Mental Health | |
local.identifier.ariespublication | f2965xPUB110 | |
local.type.status | Published Version | |
local.contributor.affiliation | Walker, Janine, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Mackinnon, Andrew, University of Melbourne | |
local.contributor.affiliation | Batterham, Philip, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Jorm, Anthony F, University of Melbourne | |
local.contributor.affiliation | Hickie, Ian B, University of Sydney | |
local.contributor.affiliation | Jenkins (previously McCarthy), Affrica, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Fenech, Michael, CSIRO Human Nutrition | |
local.contributor.affiliation | Christensen, Helen, College of Medicine, Biology and Environment, ANU | |
local.bibliographicCitation.issue | 1 | |
local.bibliographicCitation.startpage | 45 | |
local.bibliographicCitation.lastpage | 54 | |
local.identifier.doi | 10.1192/bjp.bp.109.075291 | |
local.identifier.absseo | 920209 - Mental Health Services | |
dc.date.updated | 2016-02-24T08:09:04Z | |
local.identifier.scopusID | 2-s2.0-77954600956 | |
local.identifier.thomsonID | 000279596900010 | |
Collections | ANU Research Publications |
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