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Interleukin-15 mediates potent antiviral responses via an Interferon-dependent mechanism

Foong, Yvonne; Jans, David A; Rolph, Michael S; Gahan, M E; Mahalingam, Surendran

Description

Interleukin-15 (IL-15) is a potent growth factor for activated T and natural killer (NK) cells, stimulator of memory T cells and plays an important role in viral immunity. To investigate mechanisms underlying the antiviral activity of IL-15, a recombinant vaccinia virus (rVV) encoding murine IL-15 (VV-IL-15) was constructed. Following infection of mice with VV-IL-15, virus titres in the ovaries were significantly reduced compared to mice infected with control VV. Growth of VV-IL-15 was also...[Show more]

dc.contributor.authorFoong, Yvonne
dc.contributor.authorJans, David A
dc.contributor.authorRolph, Michael S
dc.contributor.authorGahan, M E
dc.contributor.authorMahalingam, Surendran
dc.date.accessioned2015-12-08T22:29:30Z
dc.identifier.issn0042-6822
dc.identifier.urihttp://hdl.handle.net/1885/34125
dc.description.abstractInterleukin-15 (IL-15) is a potent growth factor for activated T and natural killer (NK) cells, stimulator of memory T cells and plays an important role in viral immunity. To investigate mechanisms underlying the antiviral activity of IL-15, a recombinant vaccinia virus (rVV) encoding murine IL-15 (VV-IL-15) was constructed. Following infection of mice with VV-IL-15, virus titres in the ovaries were significantly reduced compared to mice infected with control VV. Growth of VV-IL-15 was also reduced in nude athymic mice, indicating the antiviral activity of IL-15 does not require T cells. Additionally, VV-IL-15 augmented the cytolytic activity of natural NK cells in the spleen and enhanced interferon (IFN) mRNA expression and transcription factors associated with IFN induction. Using knockout mice and antibody depletion studies, we showed for the first time that the control of VV-IL-15 replication in mice is dependent on NK cells and IFNs and, in their absence, the protective role of IL-15 is abolished.
dc.publisherAcademic Press
dc.sourceVirology
dc.subjectKeywords: growth factor; interferon; interleukin 15; messenger RNA; transcription factor; virus vector; animal experiment; animal tissue; antiviral activity; article; controlled study; cytolysis; gene construct; gene expression; knockout mouse; lymphocyte activatio Interferons; Interleukin-15; NK cells; Recombinant vaccinia virus
dc.titleInterleukin-15 mediates potent antiviral responses via an Interferon-dependent mechanism
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume393
dc.date.issued2009
local.identifier.absfor110799 - Immunology not elsewhere classified
local.identifier.ariespublicationu6800332xPUB109
local.type.statusPublished Version
local.contributor.affiliationFoong, Yvonne, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationJans, David A, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationRolph, Michael S, University of Canberra
local.contributor.affiliationGahan, M E, University of Canberra
local.contributor.affiliationMahalingam, Surendran, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.startpage228
local.bibliographicCitation.lastpage237
local.identifier.doi10.1016/j.virol.2009.07.030
dc.date.updated2016-02-24T11:37:35Z
local.identifier.scopusID2-s2.0-70349845524
CollectionsANU Research Publications

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