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Expression of T-cell receptor genes during early T-cell development

Abbey, Janice; O'Neill, Helen


Lymphoid cell development is an ordered process that begins in the embryo in specific sites and progresses through multiple differentiative steps to production of T- and B-cells. Lymphoid cell production is marked by the rearrangement process, which gives rise to mature cells expressing antigen-specific T-cell receptors (TCR) and immunoglobulins (Ig). While most transcripts arising from TCR or Ig loci reflect fully rearranged genes, germline transcripts have been identified, but these have...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Immunology and Cell Biology
DOI: 10.1038/sj.icb.7100120


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