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The histone deacetylase inhibitors LAQ824 and LBH589 do not require death receptor signaling or a functional apoptosome to mediate tumor cell death or therapeutic efficacy

Ellis, Leigh; Bots, Michael; Lindemann, Ralph K.; Bolden, Jessica E.; Newbold, Andrea; Cluse, Leonie A.; Scott, Clare L.; Strasser, Andreas; Atadja, Peter; Lowe, Scott W.; Johnstone, Ricky

Description

LAQ824 and LBH589 (panobinostat) are histone deacetylase inhibitors (HDACi) developed as cancer therapeutics and we have used the Eμ-myc lymphoma model to identify the molecular events required for their antitumor effects. Induction of tumor cell death w

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
URI: http://hdl.handle.net/1885/34037
Source: Blood
DOI: 10.1182/blood-2008-10-182758

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