The histone deacetylase inhibitors LAQ824 and LBH589 do not require death receptor signaling or a functional apoptosome to mediate tumor cell death or therapeutic efficacy
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Ellis, Leigh; Bots, Michael; Lindemann, Ralph K.; Bolden, Jessica E.; Newbold, Andrea; Cluse, Leonie A.; Scott, Clare L.; Strasser, Andreas; Atadja, Peter; Lowe, Scott W.; Johnstone, Ricky
Description
LAQ824 and LBH589 (panobinostat) are histone deacetylase inhibitors (HDACi) developed as cancer therapeutics and we have used the Eμ-myc lymphoma model to identify the molecular events required for their antitumor effects. Induction of tumor cell death w
Collections | ANU Research Publications |
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Date published: | 2009 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/34037 |
Source: | Blood |
DOI: | 10.1182/blood-2008-10-182758 |
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01_Ellis_The_histone_deacetylase_2009.pdf | 2.99 MB | Adobe PDF |
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