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Central role of PPARalpha-dependent hepatic lipid turnover in dietary steatohepatitis in mice

Ip, Emilia; Farrell, Geoffrey; Robertson, Graham; Hall, Pauline; Kirsch, Richard; Leclercq, Isabelle


We have proposed that steatohepatitis results from reactive oxygen species (ROS) acting on accumulated fatty acids to form proinflammatory lipoperoxides. Cytochrome P450 4a (Cyp4a) and Cyp2e1 are potential hepatic sources of ROS. We tested the hypothesis

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Hepatology
DOI: 10.1053/jhep.2003.50307


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