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Platelet factor 4 mediates inflammation in experimental cerebral malaria

Srivastava, Kalyan; Cockburn, Ian; Swaim, Anne Marie; Thompson, Laura E; Tripathi, Abhai; Fletcher, Craig A; Shirk, Erin M; Sun, Henry; Kowalska, Anna M; Fox-Talbot, Karen; Sullivan, David; Zavala, Fidel; Morrell, Craig N

Description

Cerebral malaria (CM) is a major complication of Plasmodium falciparum infection in children. The pathogenesis of CM involves vascular inflammation, immune stimulation, and obstruction of cerebral capillaries. Platelets have a prominent role in both immune responses and vascular obstruction. We now demonstrate that the platelet-derived chemokine, platelet factor 4 (PF4)/CXCL4, promotes the development of experimental cerebral malaria (ECM). Plasmodium-infected red blood cells (RBCs) activated...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
URI: http://hdl.handle.net/1885/33873
Source: Cell Host and Microbe
DOI: 10.1016/j.chom.2008.07.003

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