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The relationship between rash, tumour KRAS mutation status and clinical and quality of life outcomes in patients with advanced colorectal cancer treated with cetuximab in the NCIC CTG/AGITG CO.17

Sommeijer, Dirkje W; Karapetis, C. S; Zalcberg, John; Tu, Dongsheng; Jonker, Derek J; Simes, R John; Tebbutt, N.; Yip, Desmond; Price, Timothy; O’Callaghan, Chris J

Description

Background. The NCIC CTG/AGITG CO.17 trial demonstrated that cetuximab monotherapy improved overall and progression-free survival (OS and PFS) in patients previously treated for advanced colorectal cancer. A strong relationship was observed between benefit from cetuximab and development of rash. In this analysis, the association of rash and benefit from cetuximab is explored and presented by KRAS mutation status. Material and methods. Rash was graded by NCI CTC 2.0 criteria. Landmark analysis...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
URI: http://hdl.handle.net/1885/33828
Source: Acta Oncologica
DOI: 10.3109/0284186X.2013.879202

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