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A single-step assay for the Gerbich-negative allele of glycophorin C

Scott, Brendan; Easteal, Simon

Description

The Gerbich erythrocyte surface protein, glycophorin C (GYPC), can be used by Plasmodium falciparum to invade erythrocytes. The Melanesian Gerbich-negative antigenic condition (Ge(-)) is frequent in some populations where malaria is endemic, suggesting that it protects against malaria. We have determined as precisely as possible the breakpoint of the chromosomal deletion that causes the Ge(-) condition by comparing the partial GYPC sequence of a Papuan Ge(-/-) homozygous individual with known...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
URI: http://hdl.handle.net/1885/33801
Source: Blood cells, Molecules and Diseases
DOI: 10.1016/j.bcmd.2008.02.009

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