Deficiency in Endothelin Receptor B Reduces Proliferation of Neuronal Progenitors and Increases Apoptosis in Postnatal Rat Cerebellum
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Vidovic, Maria; Chen, Ming-Ming; Lu, Qun-Ying; Kalloniatis, Katherine; Martin, Ben; Tan, Abel; Lynch, Celina; Croaker, David; Cass, Daniel; Song, Zan-Min
Description
Endothelins regulate cellular functions in the mammalian brain through the endothelin receptors A and B (EDNRA and EDNRB). In this study, we investigated the role of EDNRB on cell proliferation in the cerebellum by using the spotting lethal (sl) rat, which carries a naturally occurring deletion in the EDNRB gene. Proliferating cells in the three genotypes, wild-type (+/+), heterozygous (+/sl) and homozygous mutant (sl/sl) rats were labelled by intraperitoneal injection of...[Show more]
Collections | ANU Research Publications |
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Date published: | 2008 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/33722 |
Source: | Cellular and Molecular Neurobiology |
DOI: | 10.1007/s10571-008-9292-z |
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File | Description | Size | Format | Image |
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01_Vidovic_Deficiency_in_Endothelin_2008.pdf | 399.64 kB | Adobe PDF | Request a copy |
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