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Deficiency in Endothelin Receptor B Reduces Proliferation of Neuronal Progenitors and Increases Apoptosis in Postnatal Rat Cerebellum

Vidovic, Maria; Chen, Ming-Ming; Lu, Qun-Ying; Kalloniatis, Katherine; Martin, Ben; Tan, Abel; Lynch, Celina; Croaker, David; Cass, Daniel; Song, Zan-Min

Description

Endothelins regulate cellular functions in the mammalian brain through the endothelin receptors A and B (EDNRA and EDNRB). In this study, we investigated the role of EDNRB on cell proliferation in the cerebellum by using the spotting lethal (sl) rat, which carries a naturally occurring deletion in the EDNRB gene. Proliferating cells in the three genotypes, wild-type (+/+), heterozygous (+/sl) and homozygous mutant (sl/sl) rats were labelled by intraperitoneal injection of...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
URI: http://hdl.handle.net/1885/33722
Source: Cellular and Molecular Neurobiology
DOI: 10.1007/s10571-008-9292-z

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