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Ca(2+) -permeable channels in the hepatocyte plasma membrane and their roles in hepatocyte physiology

Barritt, Gregory J; Chen, Jinglong; Rychkov, Grigori Y


Hepatocytes are highly differentiated and spatially polarised cells which conduct a wide range of functions, including intermediary metabolism, protein synthesis and secretion, and the synthesis, transport and secretion of bile acids. Changes in the concentrations of Ca2+ in the cytoplasmic space, endoplasmic reticulum (ER), mitochondria, and other intracellular organelles make an essential contribution to the regulation of these hepatocyte functions. While not yet fully understood, the spatial...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Biochimica et Biophysica Acta: International journal of Biochemistry and Biophysics
DOI: 10.1016/j.bbamcr.2008.01.016


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