Skip navigation
Skip navigation

Modulation of the proteolytic activity of the complement protease C1s by polyanions: implications for polyanion-mediated acceleration of interaction between C1s and SERPING1

Murray-Rust, Thomas A; Kerr, Felicity K; Thomas, Adele R; Wu, Tina; Yongqing, Tang; Ong, Poh C; Quinsey, Noelene S; Whisstock, James C; Wagenaar-Bos, Ineke C.; Freeman, Craig; Pike, Robert N

Description

The complement system plays crucial roles in the immune system, but incorrect regulation causes inflammation and targeting of self-tissue, leading to diseases such as systemic lupus erythematosus, rheumatoid arthritis and age-related macular degeneration. In vivo, the initiating complexes of the classical complement and lectin pathways are controlled by SERPING1 [(C1 inhibitor) serpin peptidase inhibitor, clade G, member 1], which inactivates the components C1s and MASP-2 (mannan-binding lectin...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
URI: http://hdl.handle.net/1885/33666
Source: Biochemical Journal
DOI: 10.1042/BJ20090198

Download

File Description SizeFormat Image
01_Murray-Rust_Modulation_of_the_proteolytic_2009.pdf537.24 kBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  20 July 2017/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator