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Modulation of the proteolytic activity of the complement protease C1s by polyanions: implications for polyanion-mediated acceleration of interaction between C1s and SERPING1

Murray-Rust, Thomas A; Kerr, Felicity K; Thomas, Adele R; Wu, Tina; Yongqing, Tang; Ong, Poh C; Quinsey, Noelene S; Whisstock, James C; Wagenaar-Bos, Ineke C.; Freeman, Craig; Pike, Robert N


The complement system plays crucial roles in the immune system, but incorrect regulation causes inflammation and targeting of self-tissue, leading to diseases such as systemic lupus erythematosus, rheumatoid arthritis and age-related macular degeneration. In vivo, the initiating complexes of the classical complement and lectin pathways are controlled by SERPING1 [(C1 inhibitor) serpin peptidase inhibitor, clade G, member 1], which inactivates the components C1s and MASP-2 (mannan-binding lectin...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Biochemical Journal
DOI: 10.1042/BJ20090198


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