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Proliferation markers and survival in early breast cancer

Stuart-Harris, Robin; Caldas, C; Pinder, S; Pharoah, P


We have performed a systematic review and meta-analysis of proliferation markers (Ki-67, mitotic index (MI), proliferating cell nuclear antigen (PCNA) and thymidine or bromodeoxyuridine labelling index (LI)) with respect to survival in early breast cancer. Eighty-five studies involving 32,825 patients were analysed. Ki-67 (43 studies, 15,790 patients), MI (20 studies, 7021 patients), and LI (11 studies, 7337 patients) were associated with significantly shorter overall and disease free survival,...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: The Breast
DOI: 10.1016/j.breast.2008.02.002


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