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Hepatocellular Carcinoma in the Asia pacific region

Yuen, Man-Fung; Hou, Jin-Lin; Chutaputti, Anuchit; Farrell, Geoffrey; Chan, Henry L. Y.; Amarapurkar, Deepak; Fan, Jian-Gao; Han, Kwang-Hyub; Kao, Jia-Horng; Lim, Seng-Gee; Mohamed, Rosmawati; Sollano, Jose D; Ueno, Yoshiyuki

Description

Primary liver cancer, particularly hepatocellular carcinoma (HCC) remains a significant disease worldwide. It is among the top three causes of cancer death in the Asia Pacific region because of the high prevalence of its main etiological agents, chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. In this region, the incidence of HCC has been static over recent decades. Older age is a major risk factor; the incidence increasing sharply after age 40 years. There is a male...[Show more]

dc.contributor.authorYuen, Man-Fung
dc.contributor.authorHou, Jin-Lin
dc.contributor.authorChutaputti, Anuchit
dc.contributor.authorFarrell, Geoffrey
dc.contributor.authorChan, Henry L. Y.
dc.contributor.authorAmarapurkar, Deepak
dc.contributor.authorFan, Jian-Gao
dc.contributor.authorHan, Kwang-Hyub
dc.contributor.authorKao, Jia-Horng
dc.contributor.authorLim, Seng-Gee
dc.contributor.authorMohamed, Rosmawati
dc.contributor.authorSollano, Jose D
dc.contributor.authorUeno, Yoshiyuki
dc.date.accessioned2015-12-08T22:26:21Z
dc.identifier.issn0815-9319
dc.identifier.urihttp://hdl.handle.net/1885/33620
dc.description.abstractPrimary liver cancer, particularly hepatocellular carcinoma (HCC) remains a significant disease worldwide. It is among the top three causes of cancer death in the Asia Pacific region because of the high prevalence of its main etiological agents, chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. In this region, the incidence of HCC has been static over recent decades. Older age is a major risk factor; the incidence increasing sharply after age 40 years. There is a male predilection, with male to female ratio of 3:1, except in elderly Japanese with equal sex incidence or female predominance. In most Asia-Pacific countries, chronic HBV infection accounts for 75-80% of cases; Japan, Singapore and Australia/New Zealand are exceptions because of higher prevalence of HCV infection. In spite of advances in surgery, liver transplantation and newer pharmaco/biological therapies, the survival rate has improved only slightly over recent decades, and this could be attributable to earlier diagnosis ('lead-time bias'). The majority of patients present with advanced diseases, hence reducing the chance of curative treatment. The importance of HCC may decrease in two to three decades when the prevalence of chronic HBV infection decreases as a result of the universal HBV vaccination programs implemented in late 1980s in most Asia-Pacific countries, and because of reduced incidence of medical transmission of HCV. However, transmission of HCV by injection drug use, and rising prevalence of obesity and diabetes, both independent risk factors for HCC, may partly offset this decline.
dc.publisherBlackwell Publishing Ltd
dc.sourceJournal of Gastroenterology and Hepatology
dc.subjectKeywords: Asia; cancer diagnosis; cancer incidence; cancer mortality; cancer risk; cancer surgery; cancer survival; China; early diagnosis; groups by age; hepatitis B; hepatitis C; Hong Kong; human; India; Japan; Korea; liver cell carcinoma; liver graft; Malaysia; Hepatocellular carcinoma; Incidence; Mortality and etiology; Prevalence
dc.titleHepatocellular Carcinoma in the Asia pacific region
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume24
dc.date.issued2009
local.identifier.absfor110307 - Gastroenterology and Hepatology
local.identifier.ariespublicationu4201517xPUB104
local.type.statusPublished Version
local.contributor.affiliationYuen, Man-Fung, University of Hong Kong
local.contributor.affiliationHou, Jin-Lin, Nanfang Hospital
local.contributor.affiliationChutaputti, Anuchit, Phramongkutklao Hospital
local.contributor.affiliationFarrell, Geoffrey, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationChan, Henry L. Y., Chinese University of Hong Kong
local.contributor.affiliationAmarapurkar, Deepak, Bombay Hospital and Medical Research Centre
local.contributor.affiliationFan, Jian-Gao, Shanghai Jiaotong University
local.contributor.affiliationHan, Kwang-Hyub, Yonsei University
local.contributor.affiliationKao, Jia-Horng, National Taiwan University
local.contributor.affiliationLim, Seng-Gee, National University of Singapore
local.contributor.affiliationMohamed, Rosmawati, University of Malaya
local.contributor.affiliationSollano, Jose D, University of Santo Tomas
local.contributor.affiliationUeno, Yoshiyuki, Tohoku University
local.description.embargo2037-12-31
local.bibliographicCitation.startpage346
local.bibliographicCitation.lastpage353
local.identifier.doi10.1111/j.1440-1746.2009.05784.x
dc.date.updated2016-02-24T10:40:24Z
local.identifier.scopusID2-s2.0-63049111543
local.identifier.thomsonID000264552000006
CollectionsANU Research Publications

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