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Identification of a Steap3 endosomal targeting motif essential for normal iron metabolism

Lambe, Teresa; Simpson, Robert J.; Dawson, Sarah; Bouriez-Jones, Tiphaine; Crockford, Tanya; Lepherd, Michelle; Latunde-Dada, Gladys O.; Robinson, Hannah; Raja, Kishnor B.; Campagna, Dear R.; Villarreall, Guadalupe; Ellory, J Clive; Goodnow, Christopher; Fleming, Mark D.; McKie, Andrew T.; Cornall, Richard J

Description

Hereditary forms of iron-deficiency anemia, including animal models, have taught us much about the normal physiologic control of iron metabolism. However, the discovery of new informative mutants is limited by the natural mutation frequency. To address this limitation, we have developed a screen for heritable abnormalities of red blood cell morphology in mice with single-nucleotide changes induced by the chemical mutagen ethylnitrosourea (ENU). We now describe the first strain, fragile-red,...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
URI: http://hdl.handle.net/1885/33570
Source: Blood
DOI: 10.1182/blood-2007-11-120402

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