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What's new in volume therapy in the intensive care unit?

Van Haren, Frank; Zacharowski, Kai

Description

The administration of intravenous fluid to critically ill patients is one of the most common but also one of the most fiercely debated interventions in intensive care medicine. During the past decade, a number of important studies have been published which provide clinicians with improved knowledge regarding the timing, the type and the amount of fluid they should give to their critically ill patients. However, despite the fact that many thousands of patients have been enrolled in these trials...[Show more]

dc.contributor.authorVan Haren, Frank
dc.contributor.authorZacharowski, Kai
dc.date.accessioned2015-12-08T22:25:40Z
dc.identifier.issn1753-3740
dc.identifier.urihttp://hdl.handle.net/1885/33536
dc.description.abstractThe administration of intravenous fluid to critically ill patients is one of the most common but also one of the most fiercely debated interventions in intensive care medicine. During the past decade, a number of important studies have been published which provide clinicians with improved knowledge regarding the timing, the type and the amount of fluid they should give to their critically ill patients. However, despite the fact that many thousands of patients have been enrolled in these trials of alternative fluid strategies, consensus remains elusive and practice is widely variable. Early adequate resuscitation of patients in shock followed by a restrictive strategy may be associated with better outcomes. Colloids such as modern hydroxyethyl starch are more effective than crystalloids in early resuscitation of patients in shock, and are safe when administered during surgery. However, these colloids may not be beneficial later in the course of intensive care treatment and should best be avoided in intensive care patients who have a high risk of developing acute kidney injury. Albumin has no clear benefit over saline and is associated with increased mortality in neurotrauma patients. Balanced fluids reduce the risk of hyperchloraemic acidosis and possibly kidney injury. The use of hypertonic fluids in patients with sepsis and acute lung injury warrants further investigation and should be considered experimental at this stage. Fluid therapy impacts relevant patient-related outcomes. Clinicians should adopt an individualized strategy based on the clinical scenario and best available evidence. One size does not fit all.
dc.publisherBailliere Tindall
dc.sourceBest Practice and Research in Clinical Anaesthesiology
dc.titleWhat's new in volume therapy in the intensive care unit?
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume28
dc.date.issued2014
local.identifier.absfor110310 - Intensive Care
local.identifier.ariespublicationu4425841xPUB103
local.type.statusPublished Version
local.contributor.affiliationVan Haren, Frank, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationZacharowski, Kai, Department of Anesthesiology
local.description.embargo2037-12-31
local.bibliographicCitation.startpage275
local.bibliographicCitation.lastpage283
local.identifier.doi10.1016/j.bpa.2014.06.004
dc.date.updated2015-12-08T09:07:47Z
local.identifier.scopusID2-s2.0-84927956000
CollectionsANU Research Publications

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