Reduction of vector gene expression increases foreign antigen-specific CD8+ T-cell priming
Viral vectors have been shown to induce protective CD8+ T-cell populations in animal models, but significant obstacles remain to their widespread use for human vaccination. One such obstacle is immunodominance, where the CD8+ T-cell response to a vector can suppress the desired CD8+ T-cell response to a recombinantly encoded antigen. To overcome this hurdle, we broadly reduced vector-specific gene expression. We treated a recombinant vaccinia virus, encoding antigen as a minimal peptide...[Show more]
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|Source:||Journal of General Virology|
|01_Fischer_Reduction_of_vector_gene_2007.pdf||271.71 kB||Adobe PDF||Request a copy|
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