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Reduction of vector gene expression increases foreign antigen-specific CD8+ T-cell priming

Fischer, Matthew A.; Tscharke, David; Donohue, Keri B.; Truckenmiller, Mary E.; Norbury, Christopher C.


Viral vectors have been shown to induce protective CD8+ T-cell populations in animal models, but significant obstacles remain to their widespread use for human vaccination. One such obstacle is immunodominance, where the CD8+ T-cell response to a vector can suppress the desired CD8+ T-cell response to a recombinantly encoded antigen. To overcome this hurdle, we broadly reduced vector-specific gene expression. We treated a recombinant vaccinia virus, encoding antigen as a minimal peptide...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Journal of General Virology
DOI: 10.1099/vir.0.83107-0


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