Final elucidation of the absolute configuration of the signal metabolite hormaomycin
The complete absolute configuration of hormaomycin 1a has been established by HPLC and HPLC/MS experiments with appropriately derivatized 4-propylprolines, (2S,4S)-6 and (2R,4R)-6, as well as 4-(Z)-propenylprolines. cis-5 and trans-5, and also feeding experiments with enantiomerically pure samples of the deuterium-labeled 3-(2′-nitrocyclopropyl)alanine, (2S)-3,3-[D 2]15 and (2S)-2,2′-[D2]15, and 4-(Z)-propenylproline 2′,4-[D2]-(2S,4R)-5. The latter five amino acids were prepared for the first...[Show more]
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|Source:||Chemistry, A European Journal|
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