CpG-enhanced CD8+ T Cell responses to peptide immunization are severely inhibited by B cells
Synthetic peptides encoding protective pathogen-derived epitopes represent - in principle - an ideal approach to T-cell vaccination. Empirically, however, these strategies have not been successful. In the current study, we profiled the early activation of CD8+ T cells by MHC class I-restricted peptide immunization to better understand the biology of this response. We found that CD8+ T cells proliferated robustly in response to low doses of short synthetic peptides in PBS, but failed to acquire...[Show more]
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|Source:||European Journal of Immunology|
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