Overstreet, Michael G; Freyberger, Helen; Cockburn, Ian; Chen, Yun-Chi; Tse, Sze-Wah; Zavala, Fidel
Synthetic peptides encoding protective pathogen-derived epitopes represent - in principle - an ideal approach to T-cell vaccination. Empirically, however, these strategies have not been successful. In the current study, we profiled the early activation of CD8+ T cells by MHC class I-restricted peptide immunization to better understand the biology of this response. We found that CD8+ T cells proliferated robustly in response to low doses of short synthetic peptides in PBS, but failed to acquire...[Show more]
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.