Skip navigation
Skip navigation

Insights into the role of STAT3 in human lymphocyte differentiation as revealed by the hyper-IgE syndrome

Tangye, Stuart; Cook, Matthew; Fulcher, David

Description

"Experiments of nature" due to single gene mutations resulting in human immunodeficiency states have revealed critical roles for several genes in regulating lymphocyte development and the generation of protective immunity. Recently, heterozygous mutations in STAT3 were found to cause autosomal dominant hyper-IgE syndrome, a condition affecting not only the immune system but also other mesenchymal and ectodermal tissues, including bones, cranium, teeth, and skin. STAT proteins operate to...[Show more]

dc.contributor.authorTangye, Stuart
dc.contributor.authorCook, Matthew
dc.contributor.authorFulcher, David
dc.date.accessioned2015-12-08T22:25:31Z
dc.identifier.issn0022-1767
dc.identifier.urihttp://hdl.handle.net/1885/33470
dc.description.abstract"Experiments of nature" due to single gene mutations resulting in human immunodeficiency states have revealed critical roles for several genes in regulating lymphocyte development and the generation of protective immunity. Recently, heterozygous mutations in STAT3 were found to cause autosomal dominant hyper-IgE syndrome, a condition affecting not only the immune system but also other mesenchymal and ectodermal tissues, including bones, cranium, teeth, and skin. STAT proteins operate to integrate signals from surface receptors, including cytokine receptors, that regulate growth and differentiation of multiple cell lineages. In this article, we will review how the study of STAT3 deficiency in humans and mice has highlighted nonredundant roles of STAT3, and of specific cytokines, in diverse cellular processes such as antimicrobial immunity and protection at epithelial barriers, the generation of functional humoral immune responses, bone formation, and keratinocyte biology.
dc.publisherAmerican Association of Immunologists
dc.sourceJournal of Immunology
dc.source.urihttp://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19109129
dc.subjectKeywords: interferon; interleukin 10; interleukin 12; interleukin 2; interleukin 21; interleukin 23; interleukin 4; interleukin 6; interleukin 7; interleukin 9; Janus kinase 3; protein kinase TYK2; STAT1 protein; STAT3 protein; STAT5b protein; cytokine; STAT3 prote
dc.titleInsights into the role of STAT3 in human lymphocyte differentiation as revealed by the hyper-IgE syndrome
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume182
dc.date.issued2009
local.identifier.absfor110799 - Immunology not elsewhere classified
local.identifier.ariespublicationu6800332xPUB102
local.type.statusPublished Version
local.contributor.affiliationTangye, Stuart, Garvan Institute of Medical Research
local.contributor.affiliationCook, Matthew, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationFulcher, David, Westmead Hospital
local.description.embargo2037-12-31
local.bibliographicCitation.issue1
local.bibliographicCitation.startpage21
local.bibliographicCitation.lastpage28
dc.date.updated2016-02-24T11:37:31Z
local.identifier.scopusID2-s2.0-59849121375
local.identifier.thomsonID000262057200006
CollectionsANU Research Publications

Download

File Description SizeFormat Image
01_Tangye_Insights_into_the_role_of_2009.pdf582.17 kBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator