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Insights into the role of STAT3 in human lymphocyte differentiation as revealed by the hyper-IgE syndrome

Tangye, Stuart; Cook, Matthew; Fulcher, David


"Experiments of nature" due to single gene mutations resulting in human immunodeficiency states have revealed critical roles for several genes in regulating lymphocyte development and the generation of protective immunity. Recently, heterozygous mutations in STAT3 were found to cause autosomal dominant hyper-IgE syndrome, a condition affecting not only the immune system but also other mesenchymal and ectodermal tissues, including bones, cranium, teeth, and skin. STAT proteins operate to...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Journal of Immunology


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