Influence of translation efficiency of homologous viral proteins on the endogenous presentation of CD8+ T cell epitopes
Tellam, Judy; Fogg, Mark H.; Rist, Michael; Connolly, Geoff; Tscharke, David; Webb, Natasha; Heslop, Lea; Wang, Fred; Khanna, Rajiv
Description
A significant proportion of endogenously processed CD8+ T cell epitopes are derived from newly synthesized proteins and rapidly degrading polypeptides (RDPs). It has been hypothesized that the generation of rapidly degrading polypeptides and CD8+ T cell epitopes from these RDP precursors may be influenced by the efficiency of protein translation. Here we address this hypothesis by using the Epstein-Barr virus-encoded nuclear antigen 1 protein (EBNA1), with or without its internal...[Show more]
Collections | ANU Research Publications |
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Date published: | 2007 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/33440 |
Source: | Journal of Experimental Medicine |
DOI: | 10.1084/jem.20062508 |
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01_Tellam_Influence_of_translation_2007.pdf | 1.7 MB | Adobe PDF | Request a copy |
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