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Influence of translation efficiency of homologous viral proteins on the endogenous presentation of CD8+ T cell epitopes

Tellam, Judy; Fogg, Mark H.; Rist, Michael; Connolly, Geoff; Tscharke, David; Webb, Natasha; Heslop, Lea; Wang, Fred; Khanna, Rajiv


A significant proportion of endogenously processed CD8+ T cell epitopes are derived from newly synthesized proteins and rapidly degrading polypeptides (RDPs). It has been hypothesized that the generation of rapidly degrading polypeptides and CD8+ T cell epitopes from these RDP precursors may be influenced by the efficiency of protein translation. Here we address this hypothesis by using the Epstein-Barr virus-encoded nuclear antigen 1 protein (EBNA1), with or without its internal...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Journal of Experimental Medicine
DOI: 10.1084/jem.20062508


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