Skip navigation
Skip navigation

Influence of translation efficiency of homologous viral proteins on the endogenous presentation of CD8+ T cell epitopes

Tellam, Judy; Fogg, Mark H.; Rist, Michael; Connolly, Geoff; Tscharke, David; Webb, Natasha; Heslop, Lea; Wang, Fred; Khanna, Rajiv

Description

A significant proportion of endogenously processed CD8+ T cell epitopes are derived from newly synthesized proteins and rapidly degrading polypeptides (RDPs). It has been hypothesized that the generation of rapidly degrading polypeptides and CD8+ T cell epitopes from these RDP precursors may be influenced by the efficiency of protein translation. Here we address this hypothesis by using the Epstein-Barr virus-encoded nuclear antigen 1 protein (EBNA1), with or without its internal...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
URI: http://hdl.handle.net/1885/33440
Source: Journal of Experimental Medicine
DOI: 10.1084/jem.20062508

Download

File Description SizeFormat Image
01_Tellam_Influence_of_translation_2007.pdf1.7 MBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  20 July 2017/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator