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Muscle-specific GSTM2-2 on the luminal side of the sarcoplasmic reticulum modifies RyR ion channel activity

Wei, Lan; Abdellatif , Yasser; Liu, Dan; Kimura, Takashi; Coggan, Marjorie; Gallant, Esther; Beard, Nicole; Board, Philip; Dulhunty, Angela

Description

We show that a glutathione transferase (GST) protein, which is recognised by an antibody against the muscle-specific human GSTM2-2 (hGSTM2-2), is associated with the lumen of the sarcoplasmic reticulum (SR) of cardiac muscle, but not skeletal muscle. We further show that hGSTM2-2 modifies both cardiac and skeletal ryanodine receptor (RyR) activity when it binds to the luminal domain of the RyR channel complex. The properties of hGSTM2-2 were compared with those of the calsequestrin (CSQ), a...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
URI: http://hdl.handle.net/1885/33415
Source: The International Journal of Biochemistry and Cell Biology
DOI: 10.1016/j.biocel.2007.12.019

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