Wei, Lan; Abdellatif , Yasser; Liu, Dan; Kimura, Takashi; Coggan, Marjorie; Gallant, Esther; Beard, Nicole; Board, Philip; Dulhunty, Angela
We show that a glutathione transferase (GST) protein, which is recognised by an antibody against the muscle-specific human GSTM2-2 (hGSTM2-2), is associated with the lumen of the sarcoplasmic reticulum (SR) of cardiac muscle, but not skeletal muscle. We further show that hGSTM2-2 modifies both cardiac and skeletal ryanodine receptor (RyR) activity when it binds to the luminal domain of the RyR channel complex. The properties of hGSTM2-2 were compared with those of the calsequestrin (CSQ), a...[Show more]
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