Cockburn, Ian; Chen, Yun-Chi; Overstreet, Michael G; Lees , Jason R; van Rooijen, Nico; Farber, Donna L; Zavala, Fidel
Immunization with irradiated sporozoites is currently the most effective vaccination strategy against liver stages of malaria parasites, yet the mechanisms underpinning the success of this approach are unknown. Here we show that the complete development of protective CD8+ T cell responses requires prolonged antigen presentation. Using TCR transgenic cells specific for the malaria circumsporozoite protein, a leading vaccine candidate, we found that sporozoite antigen persists for over 8 weeks...[Show more]
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