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Chemoenzymatic approaches to lycorine-type Amaryllidaceae alkaloids: total syntheses of ent -lycoricidine, 3- epi-ent -lycoricidine and 4-deoxy-3- epi-ent -lycoricidine

Matveenko, Maria; Kokas, Okanya; Banwell, Martin; Willis, Anthony


The readily available and enzymatically derived cis-1,2-dihydrocatechol 4 has been elaborated, over 11 steps including an Overman rearrangement, into the non-natural enantiomer, (-)-1, of the alkaloid lycoricidine [(+)-1]. Related chemistries have provided analogues 18, 19, and 26.

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Organic Letters
DOI: 10.1021/ol701552r


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