Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection
Johnson, Andy L; Aravind, L; Schulzhenko, Natalia; Morgun, Andre; Choi, See-Young; Crockford, Tanya; Lambe, Teresa; Domaschenz, Heather; Kucharska, Edyta; Zhang, Lixin; Garcia De Vinuesa, Maria Carola; Lenardo, Michael J.; Goodnow, Christopher; Cornall, Richard J; Schwartz, Ronald H.
T cell antigen receptor (TCR) signaling in CD4+CD8+ double-positive thymocytes determines cell survival and lineage commitment, but the genetic and molecular basis of this process is poorly defined. To address this issue, we used ethylnitrosourea mutagenesis to identify a previously unknown T lineage-specific gene, Themis, which is critical for the completion of positive selection. Themis contains a tandem repeat of a unique globular domain (called 'CABIT' here) that includes a cysteine motif...[Show more]
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