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Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection

Johnson, Andy L; Aravind, L; Schulzhenko, Natalia; Morgun, Andre; Choi, See-Young; Crockford, Tanya; Lambe, Teresa; Domaschenz, Heather; Kucharska, Edyta; Zhang, Lixin; Garcia De Vinuesa, Maria Carola; Lenardo, Michael J.; Goodnow, Christopher; Cornall, Richard J; Schwartz, Ronald H.

Description

T cell antigen receptor (TCR) signaling in CD4+CD8+ double-positive thymocytes determines cell survival and lineage commitment, but the genetic and molecular basis of this process is poorly defined. To address this issue, we used ethylnitrosourea mutagenesis to identify a previously unknown T lineage-specific gene, Themis, which is critical for the completion of positive selection. Themis contains a tandem repeat of a unique globular domain (called 'CABIT' here) that includes a cysteine motif...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
URI: http://hdl.handle.net/1885/33280
Source: Nature Immunology
DOI: 10.1038/ni.1769

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