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Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production

Randall, Katrina; Lambe, Teresa; Johnson, Andy L; Treanor, Bebhinn; Kucharska, Edyta; Domaschenz, Heather; Whittle, Belinda; Tze, Lina; Enders, Anselm; Crockford, Tanya; Bouriez-Jones, Tiphaine; Alston, Duncan; Cyster, Jason G; Lenardo, Michael J.; Mackay, Fabienne; Dennick, Elissa K.; Tangye, Stuart; Chan, Tyani D.; Camidge, Tahra; Brink, Robert; Garcia De Vinuesa, Maria Carola; Batista, Facundo D.; Cornall, Richard J; Goodnow, Christopher

Description

To identify genes and mechanisms involved in humoral immunity, we did a mouse genetic screen for mutations that do not affect the first wave of antibody to immunization but disrupt response maturation and persistence. The first two mutants identified had

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
URI: http://hdl.handle.net/1885/33188
Source: Nature Immunology
DOI: 10.1038/ni.1820

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