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Anti-HHV-6 IgG titer significantly predicts subsequent relapse risk in multiple sclerosis

Simpson, Steve; Taylor, Bruce; Dwyer, Dominic E; Taylor, Janette; Blizzard, Leigh; Ponsonby, Anne-Louise; Pittas, Fotini; Dwyer, Terence; Van Der Mei, Ingrid


Background: Some of the strongest associations with MS onset are for human herpesviruses, particularly Epstein-Barr virus (EBV) and human herpesvirus 6 (HHV-6). Their role in MS clinical course is less clear, however.Methods: Prospective cohort of 198 persons with clinically definite MS, followed 2002-5, and serum samples obtained from all subjects at study entry to measure anti-HHV-6 and anti-EBV (Epstein-Barr nuclear antigen [EBNA] and viral capsid antigen [VCA]) IgG titers. Association with...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
Source: Multiple Sclerosis
DOI: 10.1177/1352458511428081


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