A mutation in a chromosome condensin II subunit, kleisin, specifically disrupts T cell development
Gosling, Katharine; Makaroff, Lydia; Theodoratos, Angelo; Kim, Yong Hee; Whittle, Belinda; Rui, Lixin; Wu, Hua; Hong, Nancy A; Kennedy, Gavin; Fritz, Julie-Anne; Yates (previously Loy), Adele; Goodnow, Christopher; Fahrer, Aude
Condensins are ubiquitously expressed multiprotein complexes that are important for chromosome condensation and epigenetic regulation of gene transcription, but whose specific roles in vertebrates are poorly understood. We describe a mouse strain, nessy,
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