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Understanding the physics of oligonucleotide microarrays: the Affymetrix spike-in data reanalysed

Burden, Conrad


The Affymetrix U95 and U133 Latin-Square spike-in datasets are reanalysed, together with a dataset from a version of the U95 spike-in experiment without a complex non-specific background. The approach uses a physico-chemical model which includes the effects of the specific and non-specific hybridization and probe folding at the microarray surface, target folding and hybridization in the bulk RNA target solution and duplex dissociation during the post-hybridization washing phase. The model...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Physical Biology
DOI: 10.1088/1478-3975/5/1/016004


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