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Dysregulation of germinal centres in autoimmune disease

Garcia De Vinuesa, Maria Carola; Sanz, Inaki; Cook, Matthew


In germinal centres, somatic hypermutation and B cell selection increase antibody affinity and specificity for the immunizing antigen, but the generation of autoreactive B cells is an inevitable by-product of this process. Here, we review the evidence that aberrant selection of these autoreactive B cells can arise from abnormalities in each of the germinal centre cellular constituents B cells, T follicular helper cells, follicular dendritic cells and tingible body macrophages or in the supply...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Nature Reviews Immunology
DOI: 10.1038/nri2637


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