Dysregulation of germinal centres in autoimmune disease
In germinal centres, somatic hypermutation and B cell selection increase antibody affinity and specificity for the immunizing antigen, but the generation of autoreactive B cells is an inevitable by-product of this process. Here, we review the evidence that aberrant selection of these autoreactive B cells can arise from abnormalities in each of the germinal centre cellular constituents B cells, T follicular helper cells, follicular dendritic cells and tingible body macrophages or in the supply...[Show more]
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|Source:||Nature Reviews Immunology|
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