Skip navigation
Skip navigation
Open Research will be down for maintenance between 8:00 and 8:15 am on Tuesday, December 1 2020.

The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment

Yu, Di; Rao, Sudha; Tsai, Louis M.; Lee, Sau Kuen (Candice); He, Yiqing; Sutcliffe, Elissa; Srivastava, Monika; Linterman, Michelle; Zheng, Lei; Simpson, Nick; Ellyard, Julia; Parish, Ian; Ma, Cindy; Li, Qi-Jing; Mackay, Charles R; Garcia De Vinuesa, Maria Carola; Parish, Christopher


Follicular helper T (Tfh) cells provide selection signals to germinal center B cells, which is essential for long-lived antibody responses. High CXCR5 and low CCR7 expression facilitates their homing to B cell follicles and distinguishes them from T helper 1 (Th1), Th2, and Th17 cells. Here, we showed that Bcl-6 directs Tfh cell differentiation: Bcl-6-deficient T cells failed to develop into Tfh cells and could not sustain germinal center responses, whereas forced expression of Bcl-6 in CD4+...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Immunity
DOI: 10.1016/j.immuni.2009.07.002


File Description SizeFormat Image
01_Yu_The_Transcriptional_Repressor_2009.pdf1.96 MBAdobe PDF    Request a copy

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator