The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment
Yu, Di; Rao, Sudha; Tsai, Louis M.; Lee, Sau Kuen (Candice); He, Yiqing; Sutcliffe, Elissa; Srivastava, Monika; Linterman, Michelle; Zheng, Lei; Simpson, Nick; Ellyard, Julia; Parish, Ian; Ma, Cindy; Li, Qi-Jing; Parish, Christopher; Mackay, Charles R; Garcia De Vinuesa, Maria Carola
Follicular helper T (Tfh) cells provide selection signals to germinal center B cells, which is essential for long-lived antibody responses. High CXCR5 and low CCR7 expression facilitates their homing to B cell follicles and distinguishes them from T helper 1 (Th1), Th2, and Th17 cells. Here, we showed that Bcl-6 directs Tfh cell differentiation: Bcl-6-deficient T cells failed to develop into Tfh cells and could not sustain germinal center responses, whereas forced expression of Bcl-6 in CD4+...[Show more]
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