Despite slow catalysis and confused substrate specificity, all ribulose bisphosphate carboxylases may be nearly perfectly optimized
The cornerstone of autotrophy, the CO2-fixing enzyme, D-ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco), is hamstrung by slow catalysis and confusion between CO2 and O2 as substrates, an "abominably perplexing" puzzle, in Darwin's parlance. Here we argue that these characteristics stem from difficulty in binding the featureless CO2 molecule, which forces specificity for the gaseous substrate to be determined largely or completely in the transition state. We hypothesize that natural...[Show more]
|Collections||ANU Research Publications|
|Source:||PNAS - Proceedings of the National Academy of Sciences of the United States of America|
|01_Tcherkez_Despite_slow_catalysis_and_2006.pdf||867.85 kB||Adobe PDF||Request a copy|
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.