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2'-Methoxy-6-methylflavone: A novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA A receptors

Karim, Nasiara; Curmi, John; Gavande, Navnath; Johnston, Graham A R; Hanrahan, Jane R; Tierney, Mary (Louise); Chebib, Mary

Description

BACKGROUND AND PURPOSE Flavonoids are known to have anxiolytic and sedative effects mediated via actions on ionotropic GABA receptors. We sought to investigate this further. EXPERIMENTAL APPROACH We evaluated the effects of 2′-methoxy-6-methylflavone (2

dc.contributor.authorKarim, Nasiara
dc.contributor.authorCurmi, John
dc.contributor.authorGavande, Navnath
dc.contributor.authorJohnston, Graham A R
dc.contributor.authorHanrahan, Jane R
dc.contributor.authorTierney, Mary (Louise)
dc.contributor.authorChebib, Mary
dc.date.accessioned2015-12-08T22:23:15Z
dc.identifier.issn0007-1188
dc.identifier.urihttp://hdl.handle.net/1885/32783
dc.description.abstractBACKGROUND AND PURPOSE Flavonoids are known to have anxiolytic and sedative effects mediated via actions on ionotropic GABA receptors. We sought to investigate this further. EXPERIMENTAL APPROACH We evaluated the effects of 2′-methoxy-6-methylflavone (2
dc.publisherNature Publishing Group
dc.sourceBritish Journal of Pharmacology
dc.subjectKeywords: 2' methoxy 6 methylflavone; 3 amino 2 (3 carboxypropyl) 6 (4 methoxyphenyl)pyridazinium bromide; 4 aminobutyric acid; 4 aminobutyric acid A receptor; 4 aminobutyric acid A receptor alpha2beta2; anxiolytic agent; barbituric acid derivative; bicuculline; ch a1- and a2-containing GABA A receptors; anxiolytic agents; dissociated hippocampal neurons; flavonoids; GABA (?-aminobutyric acid); GABA A receptors; sedative effects; Xenopus oocytes
dc.title2'-Methoxy-6-methylflavone: A novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA A receptors
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume165
dc.date.issued2012
local.identifier.absfor060110 - Receptors and Membrane Biology
local.identifier.ariespublicationu4693331xPUB95
local.type.statusPublished Version
local.contributor.affiliationKarim, Nasiara, University of Sydney
local.contributor.affiliationCurmi, John, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationGavande, Navnath, University of Sydney
local.contributor.affiliationJohnston, Graham A R, University of Sydney
local.contributor.affiliationHanrahan, Jane R, University of Sydney
local.contributor.affiliationTierney, Mary (Louise), College of Medicine, Biology and Environment, ANU
local.contributor.affiliationChebib, Mary, University of Sydney
local.description.embargo2037-12-31
local.bibliographicCitation.issue4
local.bibliographicCitation.startpage880
local.bibliographicCitation.lastpage896
local.identifier.doi10.1111/j.1476-5381.2011.01604.x
dc.date.updated2016-02-24T11:18:16Z
local.identifier.scopusID2-s2.0-80555136104
local.identifier.thomsonID000299469400012
CollectionsANU Research Publications

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