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Treatment of mice with fenbendazole attenuates allergic airways inflammation and Th2 cytokine production in a model of asthma

Cai, Yeping; Zhou, Jiansheng; Webb, Dianne

Description

Mouse models have provided a significant insight into the role of T-helper (Th) 2 cytokines such as IL-5 and IL-13 in regulating eosinophilia and other key features of asthma. However, the validity of these models can be compromised by inadvertent infection of experimental mouse colonies with pathogens such as oxyurid parasites (pinworms). While the benzimidazole derivative, fenbendazole (FBZ), is commonly used to treat such outbreaks, the effects of FBZ on mouse models of Th2 disease are...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
URI: http://hdl.handle.net/1885/32698
Source: Immunology and Cell Biology
DOI: 10.1038/icb.2009.47

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